Silver Impregnated Dressing
Dressings containing ionic silver for surgical wounds have been examined in patients with cancer for effects on the incidence of surgical site infections.
Sertraline
Sertraline is in the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants. It works by increasing the amounts of serotonin in the brain. Sertraline has been examined as an intervention for depression, hot flashes, and fatigue in patients with cancer.
Serotonin 5HT3 Receptor Antagonists (5HT3)
5-hydroxytryptamine (5HT3) receptor antagonists are a class of antiemetic drug used to relieve nausea and vomiting associated with chemotherapy. At this time, four 5HT3 receptor antagonists are approved by the U.S. Food and Drug Administration, ondansetron, granisetron, dolasetron, and palonosetron. There is limited evidence that palonosetron may have a greater efficacy in the prevention of delayed chemotherapy-induced nausea and vomiting.
Selenium
Selenium is an essential mineral found in soil, brazil nuts, fish, and other seafood, poultry, and whole grains. The recommended daily dose is 55 micrograms (mcg) for adults and 60—70 mcg for pregnant or breastfeeding women. Selenium is thought to help preserve elasticity in body tissues, slow aging, improve oxygenation to the heart, and help prevent blood clotting. Selenium was evaluated in patients with cancer for treatment of mucositis.
Scrambler Therapy
Scrambler therapy is a noninvasive approach that uses surface electrostimulation on dermatomes to "scramble" the transmission of pain messages to the brain. Scrambler therapy has been examined in patients with cancer for its effect on neuropathic pain and neuropathy symptoms.
Samital® Mouth Rinse
Samital® is a combination of botanical extracts from bilberry, macleaya cordata fruits, and Echinaceas angustifolia roots. These extracts have antifungal, antiviral, analgesic, and antinflammatory properties, as well as activity to protect mucosa and improve fibroblast proliferation. This solution was examined for its effect in prevention and management of oral mucositis.
Salvia Officinalis
This plant is commonly known as kitchen or common sage, and its extract can be used in tablet form as an herbal remedy. Though the mechanism of action of the extract is still unknown, the primary biologically active agent of sage is thought to be the plant's essential oil. The extract reportedly has anti-inflammatory, antihydrotic, antibiotic, hypoglycemic, estrogenic, astringent, and antispasmodic properties.
Salivary Stimulation
Salivary stimulation is aimed at preventing functional loss of salivary gland activity. Stimulation can be done mechanically, using chewing gum like stimulation, pharmacologically, or electrically using a transcutaneous electrical nerve stimulation. Salivery stimulation has been studied in patients with cancer for effects on oral mucositis.
Saline
Saline is a solution of sodium chloride in water, and it can be used for multiple purposes including intravenous infusions, nasal irrigation, eye drops, and wound cleaning. Several formulations of saline are available with added ingredients including Lactated Ringer's solution and Acetated Ringer's solution.
Pycnogenol
Pycnogenol is an extract of pinus pinaster bark. It is believed to interfere with inflammation. This extract was studied for its effect on oral mucositis in patients with cancer.