The COVID-19 pandemic has intensified the social isolation of individuals with cancer. Studies about how to address social isolation among patients with cancer are limited, yet data from other high-risk populations can inform oncology nursing practice. This literature review of evidence-based clinical interventions provides a foundation for clinical oncology nursing practice. With the use of technology, institutional resources, and community resources, oncology nurses can tailor physical activity, psychotherapy, and socialization interventions to reduce the negative psychosocial outcomes of isolation.