I read "Validating the Clinical Research Nursing Domain of Practice" by Castro et al. (2011) with great attention. Oncology has long recognized clinical trials as an area of specialization for nursing (Hubbard & DeVita, 1976). What began as a role in administering investigational chemotherapy for U.S. nurses has evolved into an internationally recognized specialty practice for nursing across all therapeutic areas (Spilsbury et al., 2008). I'm pleased that the Oncology Nursing Society continues to champion clinical trial nursing.