With an increase in the number of patients with cancer receiving treatment in the ambulatory setting, a need exists to evaluate lean approaches to provide safe, effective, and timely care delivery. Acuity-based scheduling (ABS) was implemented across the regional ambulatory care centers of a National Cancer Institute–designated comprehensive cancer center. ABS involved templates and a reconfiguration of clinical space and staff according to acuity levels. Results suggest improvement in wait times, capacity, infusion hours, chair use rate, patient visits, chair turns, average infusion length, and patient satisfaction.