In the past several years, the field of immuno-oncology has exploded. Checkpoint inhibitors (PD-1, PD-L1, CTLA-4), chimeric antigen receptor (CAR) T-cell therapy, and monoclonal antibodies can add years to the lives of patients with certain malignancies. But to add quality to those years, advanced practice nurses must be able to recognize and treat immune-related adverse effects (irAEs).