Oncology nurses handle hazardous drugs when they administer medications to patients in inpatient and outpatient settings. Guidelines for the safe handling of hazardous drugs have been in place since the late 1980s; however, confusion still remains about the proper handling of the substances. Institutional policies vary and the use of personal protective equipment is inconsistent. In an effort to provide a safe working environment, nurses should be aware of the potential health risks of handling hazardous drugs and adhere to recommended guidelines to prevent occupational exposure.