A plus sign can mean many things depending on the context—math for a school-aged child, a positive balance for an accountant, or, for us (the authors), new beginnings and new additions to our families. We were thrilled with the news that we were both expecting at the same time and that our children would be growing up together. As reality set in, however, we realized that this timing would have an incredible impact on our clinical oncology care teams because the two of us would be on leave at the same time.