Although the mechanisms of action for all cancer types are not fully known, best practice recommends promoting a healthy lifestyle while avoiding certain substances. Based on environmental science, the precautionary principle is a guideline that suggests that preventive action should be taken when the effects of a substance are unknown or disputed. Oncology nurses and maternal child healthcare professionals can improve cancer prevention through efforts during pregnancy, childhood, adolescence, and adulthood. This article reviews the application of the precautionary principle during critical periods of growth and development and provides recommendations that may prevent epigenetic changes and reduce the risk for cancer.