Precision medicine has revolutionized multiple facets of care across the cancer trajectory, from prevention through treatment. Sometimes referred to as personalized medicine, precision medicine uses information contained in an individual’s genes, as well as biomarkers and genetic alterations detected in tumor cells, to prevent, diagnose, and treat malignancy. It can provide valuable information about an individual’s risk for developing malignancy, facilitate an accurate diagnosis, inform or revise a plan of treatment, or offer information about prognosis.