The 21st Century Cures Act is designed to make healthcare information more accessible and transparent to patients and the healthcare team. The provisions to address information blocking dictate that health information such as clinical notes, laboratory test results, and imaging reports in an electronic health record must be immediately available to patients through a secure online portal. Implementation of the 21st Century Cures Act mandate has presented challenges and benefits for patients and the healthcare team. Challenges can be addressed through awareness, continued support for patients and the healthcare care team, and by sharing experiences.