Stress affects people’s physiologic and mental well-being. Compounded stress from natural disasters, intergenerational trauma, stigma, and mistrust of the dominant society may lead to illness and potential oncologic disorders. The concepts of diversity, equity, and inclusion have become mainstays of nurses’ interactions with patients. Nurses may need to support self-care for those experiencing intergenerational trauma and natural disasters, such as Native Hawai‘ian and Other Pacific Islander (NHOPI) individuals. This person-centered approach is ideal for the oncology nurse to implement in practice.