Your patient has a new or unusual symptom. What tests would you request first, and how are they interpreted? This column, dedicated to advanced practice nurses and experienced oncology nurses, will discuss a variety of assessment and diagnostic techniques to help in the evaluation and management of clinical problems. If you are interested in writing for this column, contact Associate Editor Catherine Burke, MS, APRN, BC, ANP, AOCN®, via e-mail at cburke@mdanderson.org.