Antunes, H.S., Ferreira, E.M., de Matos, V.D., Pinheiro, C.T., & Ferreira, C.G. (2008). The impact of low power laser in the treatment of conditioning-induced oral mucositis: A report of 11 clinical cases and their review. Medicina Oral, Patología Oral y Cirugía Bucal, 13(3), 189–192.
Low-power laser therapy (LPLT) versus placebo
Only dentists knew the randomization.
Low level intensity laser: InGaAIP diode laser—660 nm, 46.7 mW
Predental care
Oral care: Extrasoft toothbrushes; dental paste with a peroxidase system after meals, and alcohol-free chlorhexidine solution until neutrophil recovery TID
Evaluations were performed daily by one dentist (not blinded) and three nurses (blinded).
Crossover allowed for control group patients who developed grade 4 oral mucositis.
The sample was comprised of 38 patients with HSCT.
Adults M =36.5/36.8
Women = 7/8
Men = 12/11
Autologous HSCT = 5/5
Allogenic HSCT = 14/14
Centro de Transplante de Medula Ossea
January 2004-May 2005
Randomized, placebo-controlled, quantity and prospective clinical trial
WHO scale
OMAS
VAS
All patients completed the study; none were lost to follow-up or excluded.
LPLT less intense oral mucositis
Grade 0 = 1, 63.2%, 12 of 19 versus 10.5%, 2 of 19 (p < 0.001)
6 LPLT, 31.5% WHO Grade 2
94.7% WHO 0–2
Control group was the opposite (data not provided) (p < 0.001).
Mucositis-free survival hazard ration grade 2, 3, and 4 was 0.41 (p = 0.002); the hazard ration grade for grade 3 and 4 was 0.07.
OMAS = 84.2% (16) patients receiving laser treatment stayed on a weighted average zone of 0–2.9 versus 26.3% (5) (p = 0.007).
Patients receiving laser treatment presented with small extension of ulcerous area (p = 0.003).
Control group showed mucositis earlier (D + 5) than laser group (D + 6) (p = 0.67, NS).
Longer duration 6 versus 9 (p = 0.13, NS)
Longer to heal (p = 0.15)
No differences in presence and intensity of pain
No differences in blood cultures
The level of agreement among evaluators was 81.7%.
Sample size
Implies difference when p value is not significant
Narrative frequently does not match p values.