Auret, K., Roger Goucke, C., Ilett, K.F., Page-Sharp, M., Boyd, F., & Oh, T.E. (2006). Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain. Therapeutic Drug Monitoring, 28, 359–366.
To elucidate the pharmacology of methadone in palliative care patients with advanced cancer who have switched from morphine to methadone
The study had a small sample size.
Further studies, to determine if methadone is better than morphine for the treatment of neuropathic pain, are warranted.