Brami, C., Bao, T., & Deng, G. (2016). Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review. Critical Reviews in Oncology/Hematology, 98, 325–334.
STUDY PURPOSE: To provide a review of best evidence for chemotherapy-induced peripheral neuropathy (CIPN) treatments
TYPE OF STUDY: Systematic review
PHASE OF CARE: Active antitumor treatment
Interventions included were vitamin E, glutamine, goshajinkigan, alpha-lipoic acid, omega-3 fatty acids, acupuncture, massage therapy, acetyl L carnitine, and physical activity. All interventions showed mixed findings, with findings suggesting that acetyl L carnitine may worsen symptoms in patients receiving chemotherapy.
Limited evidence exists to show the effectiveness of integrative therapies for the prevention or treatment of CIPN.
Very limited evidence exists for effective interventions to prevent or manage CIPN. More research is needed in this area.