Cerchietti, L. C., Navigante, A. H., Peluffo, G. D., Diament, M. J., Stillitani, I., Klein, S. A., & Cabalar, M. E. (2004). Effects of celecoxib, medroxyprogesterone, and dietary intervention on systemic syndromes in patients with advanced lung adenocarcinoma: a pilot study. Journal of Pain and Symptom Management, 27, 85–95.
Systemic-immune metabolic syndrome (SIMS) implies dysregulation of psychoneuroimmunoendocrine homeostasis, resulting in cachexia, anorexia, chronic nausea, early satiety, fatigue, tumor fever, cognitive changes, and superinfections (i.e., increased cytokines may increase cachexia-anorexia syndrome [CAS] and mediate anorexia).
The study included 15 adult outpatients with stage IIIb or IV lung adenocarcinoma.
Patients were included if they
The study was conducted in a community outpatient setting in Argentina.
The study used a pilot, open-label, uncontrolled convenience sample design.
Weekly measurements included
Cost of medications, polymeric diet, and cost of cytokine measurements should be considered.