Cornely, O.A., Ullmann, A.J., & Karthaus, M. (2003). Evidence-based assessment of primary antifungal prophylaxis in patients with hematologic malignancies. Blood, 101, 3365–3372.
Primary antifungal prophylaxis with fluconazole, itraconazole, or an amphotericin B product were evaluated in neutropenic patients with hematologic malignancies.
Not described.
Thirty-eight randomized, controlled trials of primary antifungal prophylaxis and 13 historically controlled or uncontrolled trials of primary antifungal prophylaxis.
More than 9,000 neutropenic patients with hematologic malignancies.
Recommended antifungal prophylactic regimens for patients with hematologic malignancies and their level of evidence:
Conventional chemotherapy
Allogeneic transplantation