DiPalma, J.A., Cleveland, M.V., McGowan, J., & Herrera, J.L. (2006). An open-labeled study of chronic polyethylene glycol laxative use in chronic constipation. Alimentary Pharmacology and Therapeutics, 25, 703–708.
To extend the safety data of polyethylene glycol used for chronic treatment of chronic constipation.
Polyethylene glycol laxative was administered as a single daily dose of 17 g for 12 months.
This was a randomized, open-label, single-treatment study.
Polyethylene glycol laxative is safe and effective for treating constipation in adult and older adult patients for periods up to 12 months, with no evidence of tachyphylaxis.