Engels, E.A., Lau, J., & Barza, M. (1998). Efficacy of quinolone prophylaxis in neutropenic cancer patients: A meta-analysis. Journal of Clinical Oncology, 16, 1179–1187.
DATABASES USED: MEDLINE (1966–1996); the reference lists of retrieved articles also were reviewed.
Without prophylaxis
Compared with no prophylaxis, quinolone prophylaxis decreased the risk of
Compared with trimethoprim/sulfamethoxazole prophylaxis, quinolone prophylaxis decreased the risk of
Quinolone prophylaxis did not affect the rate of
The rate of quinolone-resistant gram-negative infections was 3.0%, and the rate of quinolone-resistant gram-positive infections was 9.4% among patients who received quinolone prophylaxis, but no data were provided regarding the rate of quinolone-resistant infections among the control group. Therefore, the effect of quinolone prophylaxis on the rate of quinolone-resistant infections is unknown.