Evensen, J. F., Bjordal, K., Jacobsen, A. B., Løkkevic E. & Tausjø, J. E. (2001). Effects of Na-sucrose octasulfate on skin and mucosa reactions during radiotherapy of head and neck cancers--a randomized prospective study. Acta Oncologica, 40, 751–755.
To evaluate the protective effects of Na-sucrose octasulfate (NaSOS) on radiation-induced skin damage in patients with head and neck cancer.
Each patient was his or her own control. NaSOS was applied on one side, and the placebo was applied to the other. It was started on day 1 of radiation therapy (RT) treatment. The gel was applied twice a day during RT and for two weeks after.
Norway
The study used a quasiexperimental, double-blind, vehicle-controlled design. Each patient was his or her own control.
There was no significant protective effect with use of NaSOS.