Fenig, E., Brenner, B., Katz, A., Sulkes, J., Lapidot, M., Schachter, J., … Gutman, H. (2001). Topical Biafine and Lipiderm for the prevention of radiation dermatitis: a randomized prospective trial. Oncology Reports, 8, 305–309.
To evaluate the use of Biafine or Lipiderm to prevent radiodermatitis.
Participants were randomized to one of three trial arms: (a) Biafine, (b) Lipiderm, or the (c) control (no prophylactic treatment).
Study preparations were applied twice daily, staring 10 days prior to the beginning of radiation therapy (RT) and continuing until 10 days after treatment. Skin treatment was upgraded if necessary to steroids for grade 3 reaction antibiotics for grade 4 reactions or pause in therapy for grade 5 reactions.
Single site
The study was a randomized, controlled trial.
The study neither refutes nor supports use of these products for existing reactions. These products did not show radioprotective effects.