Fisher, J., Scott, C., Stevens, R., Marconi, B., Champion, L., Freedman, G. M., … Wong, G. (2000). Randomized phase III study comparing best supportive care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97–13. International Journal of Radiation Oncology, Biology, Physics, 48, 1307–1310.
To determine if Biafine was more effective than best supportive care (BSC) in preventing or reducing radiation (RT)-induced dermatitis.
Randomizaton to Biafine versus BSC depended on the institution and included aloe, Aquaphor, other interventions, and no treatment.
Patients were stratified by bra size: small (32ab, 34ab, 36a), medium (32c, 34c, 36bc, 38abc), or large (all others).
The study was a randomized, controlled trial.