Ghosh, S., & Dey, S. (2010). Comparing different antiemetic regimens for chemotherapy induced nausea and vomiting. International Journal of Collaborative Research on Internal Medicine and Public Health, 2, 142–156.
To compare the efficacy and safety of ondansetron, granisetron, and palonosetron used with equal dosage of dexamethasone with moderately emetogenic chemotherapy (MEC) to highly emetogenic chemotherapy (HEC)
The study was conducted in a single outpatient setting at Bankura Smmilani Medical College and Hospital in India.
All patients were in active treatment.
This was a double-blind, randomized controlled trial.
Study findings suggest that palonosetron may be more effective for CINV prevention and control with MEC. Palonosetron, as pointed out in this article, is much more expensive than the other medications used, so considering its use in the type of chemotherapy treatment where it appears to be more effective makes sense. Differences in efficacy seen over time suggest that the same drug may have the same efficacy in a patient over the course of therapy. Consideration might be given to studying this issue and the potential of switching drugs at various points.