Hajdenberg, J., Grote, T., Yee, L., Arevalo-Araujo, R., & Latimer, L.A. (2006). Infusion of palonosetron plus dexamethasone for the prevention of chemotherapy-induced nausea and vomiting. Journal of Supportive Oncology 4(9), 467-471.
To evaluate the efficacy and safety of palonosetron and dexamethasone as an antiemetic regimen
The study consisted of 33 patients.
The study was conducted at three sites.
This was a nonblinded, open-label, phase II study.
No significant differences were found in any of the outcomes of interest between groups. The report stated that the addition of dexamethasone increased in benefit in the acute interval by 12%, but this was not significant.
The study refers to a historic population as the control rather than having a control group. The historic control is not described other than that patients received palonosetron without concomitant dexamethasone.