Harris, A.C., & Jackson, J.M. (1977). Lactulose in vincristine-induced constipation. Medical Journal of Australia, 2, 573–574.
To measure the efficacy of lactulose as a treatment for vincristine-induced intractable constipation or for the prevention of vincristine-associated constipation in patients with cancer.
Patients received lactulose 20 ml BID to 25 ml TID.
This was a descriptive study.
Time-to-first bowel movement after vincristine treatment and initiation of lactulose therapy.
All patients obtained relief of constipation within two days of initiating lactulose.