Janusch, M., Fischer, M., Marsch, W., Holzhausen, H.J., Kegel, T., & Helmbold, P. (2006). The hand-foot syndrome—A frequent secondary manifestation in antineoplastic chemotherapy. European Journal of Dermatology, 16, 494–499.
Multiple interventions can be implemented to prevent or minimize PPE, including teaching patients to avoid mechanical irritation of the skin, use topical emollient creams, and use regional cooling.