Khojasteh, N.H., Zakerinia, M., Ramzi, M., & Haghshenas, M. (2000). A new regimen of MESNA (2-mercaptoethanesulfonate) effectively prevents cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplant recipients. Transplantation Proceedings, 32, 596.
Mesna was given to patients undergoing allogeneic bone marrow transplantation and administered high-dose chemotherapy. Doses were administered at 400 mg/m2 at hours 0, 1, 3, 5, 8, 11, 14, 17, and 20. Fluid also was administered at 3,000 mL/m2.
Three patients developed transient but asymptomatic hemorrhagic cystitis. One patient developed late onset but moderate hemorrhagic cystitis.