Kienzle-Horn, S., Vix, J.M., Schuitjt, C., Peil, H., Jordan, C.C., & Kamm, M.A. (2007). Comparison of bisacodyl and sodium picosulfate in the treatment of chronic constipation. Current Medical Research and Opinion, 23, 691–699.
To compare the safety and efficacy of bisacodyl and sodium picosulphate.
Patients received 5 to 10 mg of bisacodyl sugar-coated tablets or sodium picosulphate drops daily over four weeks. The study schedule included four visits: an initial screening visit followed by a seven-day baseline period, a randomization visit (1:1 basis) and two follow-up visits on days 15 and 29.
15 centers (outpatient clinics and specialist gastroenterology units) in Germany
This was a phase IV, open-label, randomized, parallel group study.
Bisacodyl and sodium picosulphate are equally tolerated and effective in the treatment of chronic constipation.