Kietpeerakool, C., Supoken, A., Laopaiboon, M., & Lumbiganon, P. (2016). Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer. Cochrane Database of Systematic Reviews, 2016, CD011732.
STUDY PURPOSE: To assess the effects of tranexamic acid for reducing blood loss in women undergoing surgery for advanced ovarian cancer
PHASE OF CARE: Active antitumor treatment
Preoperative tranexamic acid was associated with reduced loss of blood compared to placebo; however, the difference from placebo was not statistically significant, and the difference seen did not demonstrate a clearly clinically important benefit (mean difference = -248.59, 95% CI [-550.9, 53.79]). Average number of RBC units were not different between groups, although the rate of RBC transfusion was lower in those given tranexamic acid.
Evidence regarding the effectiveness of tranexamic acid from this review is inconclusive because only one study was found and reviewed.
This review provided no new information to evaluate efficacy of tranexamic acid for prevention of bleeding.