Allantoin is a chemical compound present in botanical extracts and the urine of most mammals. It is used in dermatologic preparations, and it is reported to have moisturizing effects because it increases the water content of the extracellular matrix and enhances the desquamation of layers of dead skin cells. It also is reported to promote cell proliferation, aid wound healing, and modulate inflammatory response. Emulsions containing natural oils and allantoin have been examined for their effectiveness in the management of radiodermatitis.