Lodge, J.P.A., Jonas, S., Oussoultzoglou, E., Malagó, M., Jayr, C., Cherqui, D., . . . Mimoz, O. (2005). Recombinant coagulation factor VIIa in major liver resection: A randomized, placebo-controlled, double-blind clinical trial. Anesthesiology, 102, 269–275.
Placebo versus two treatment arms of recombinant coagulation factor VIIa: 20 mcg/kg and 80 mcg/kg
Perioperative transfusion difference approached significance (P = 0.09). Mean requirements decreased with rFVIIa (P = 0.78). Blood loss during surgery decreased (P = 0.07).
A larger trial is needed for better evaluation.