Mace, J.R., Keohan, M.L., Bernardy, H., Junge, K., Niebch, G., Romeis, P., . . . Baker, L.H. (2003). Crossover randomized comparison of intravenous versus intravenous/oral mesna in soft tissue sarcoma treated with high-dose ifosfamide. Clinical Cancer Research, 9, 5829–5834.
To determine pharmacokinetics (PK) and efficacy of oral mesna
Patients were given IV mesna for the first dose and then randomized to IV or oral mesna for the following two doses. Crossover occurred at cycle two.
There were no significant differences in plasma PK between IV and oral. Rates of HC were not significant among IV and oral arms (3 of 16 for IV/IV/IV arm (90% CI 0.15 – 0.34) and 4 of 16 for IV/PO/PO arm (90% CI 0.23 – 0.52). Measurement of HC was not clearly defined.