Mantovani, G., Macciò, A., Madeddu, C., Gramignano, G., Lusso, M. R., Serpe, R., . . . Deiana, L. (2006). A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiology, Biomarkers and Prevention, 15, 1030–1034.
The integrated treatment consisted of the following components:
Patient outcomes were assessed at baseline and one, two, and four months.
Not identified
Patients were undergoing the active treatment phase of care.
This was an open, early-phase II study.
Multidimensional Fatigue Symptom Inventory–Short Form (MFSI-SF)
Compared to baseline scores, fatigue outcomes improved at two months (p = 0.22) and more so at four months (p = 0.004). No correlation existed between changes in fatigue and changes in any other variable studied.