Mentes, S.D., Unsal, D., Baran, O., Argun, G., & Ertunc, F.N. (2005). Effect of sedation with midazolam or propofol on patient’s comfort during cancer chemotherapy: A prospective, randomized, double-blind study in breast cancer patients. Journal of Chemotherapy, 17, 327–333.
The trial had three arms: Group 1 – chemotherapy control, Group 2 – chemotherapy plus midazolam, and Group 3 – chemotherapy plus propofol.
The study reported on a sample of 45 patients with breast cancer (s/p mastectomy, second chemotherapy).
Turkey
A randomized controlled trial design was used.
Clinical Global Impression Scale (CGI) for anxiety
Midazolam and propofol significantly decreased anxiety, with propofol being better.
It is unclear which groups completed the CGI measure.