National Comprehensive Cancer Network. (2015). NCCN Clinical Practice Guidelines in Oncology: Prevention and treatment of cancer-related infections [v. 2.2015]. Retrieved from https://www.nccn.org/professionals/physician_gls/f_guidelines.asp
RESOURCE TYPE: Evidence-based guideline
DATABASES USED: Not provided
KEYWORDS: Not provided
INCLUSION CRITERIA: Not provided
EXCLUSION CRITERIA: Not provided
PHASE OF CARE: Multiple phases of care
Not provided.
The guidelines recommends no prophylaxis for those with a low risk of infection; consideration of bacterial, fungal, and viral prophylaxis for intermediate risk (anticipated neutropenia 7–10 days), considerations of fluoroquinolone prophylaxis, antifungal prophylaxis until resolution of neutropenia, and viral prophylaxis during neutropenia in high-risk patients (e.g., anticipated neutropenia longer than 10 days, allogeneic HCT, acute leukemia induction or consolidation). It provides a recommended vaccination schedule for patients undergoing HCT, recommends annual influenza vaccine and pneumococcal vaccine to newly diagnosed patients based on individual assessment, and suggests fluoroquinolone prophylaxis in patients at high risk for mucositis.
The guidelines provide general recommendations for prevention and management of infection, and useful algorythms for work up and management of signs and symptoms of infection by site.