Panahi, Y., Saadat, A., Sahebkar, A., Hashemian, F., Taghikhani, M., & Abolhasani, E. (2012). Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: A pilot, randomized, open-label clinical trial. Integrative Cancer Therapies, 11, 204-211.
To evaluate the effects of ginger on acute and delayed chemotherapy-induced nausea and vomiting (CINV) in women being treated for breast cancer
Consecutive patients were alternatively assigned to the treatment or control group. Those in the treatment group were given 1.5 g ginger per day in addition to a standard antimetic regimen. The standard regimen consisted of graniestron plus dexamethasone. Treatment was given for four days.
The study was conducted at a single site in Iran.
All patients were in active antitumor treatment.
This was a randomized, open-label comparison.
The Rhodes index of nausea, vomiting, and retching was used to measure CINV.
The authors reported that patients in the treatment group had significantly less nausea in the first six hours of the study; however, no differences were found between groups at any other time point, and no differences were found between groups in terms of vomiting.
No significant differences were found between groups in CINV other than less nausea in the first six hours after chemotherapy with ginger.
These findings did not provide strong support for the efficacy of ginger in the management or prevention of acute or delayed CINV in patients receiving moderately emetogenic chemotherapy.