Postow, M.A. (2015). Managing immune checkpoint-blocking antibody side effects. American Society of Clinical Oncology 2015 Educational Book, 76–83.
RESOURCE TYPE: Expert opinion
Unable to discern any information about scope or evidence used in this article. Expert opinion.
Recommendations for the management of mild diarrhea include oral hydration, American Dietary Association diet, and lomotil four times per day. For symptoms that persist for more than three days or increase, oral or IV corticosteroids should be used, although no dosages were noted. For severe cases in which steroids do not improve diarrhea, patients should be hospitalized for IV therapy to include hydration and steroids up to 2 mg/kg twice a day. For symptoms that still persist, infliximab 5 mg/kg once every two weeks can be used.
Additional studies need to be conducted to determine the best management practice for gastrointestinal side-effect management with immune-checkpoint blocking antibodies in a variety of cancer types.