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To evaluate the effectiveness of oral pyridoxine as prophylactic therapy for Palmar-Plantar Erythrodysesthesia (PPE)
The first 15 patients were treated without prophylaxis with oral pyridoxine. The following 20 patients were given oral pyridoxine 300 mg per day for 56 days.
In group 1, 33% developed PPE—one patient developed grade 3, and four patients developed grade 2 PPE. In group 2, 40% developed PPE—three patients developed grade 3, and five patients developed grade 2 PPE.
Prophylactic use of vitamin B6 may not be useful with biweekly administrations at low dose (15–20 mg/m2) because of low frequency of PPE documented with this particular schedule.