Saito, M., & Tsukuda, M. (2010). Review of palonosetron: Emerging data distinguishing it as a novel 5 HT(3) receptor antagonist for chemotherapy induced nausea and vomiting. Expert Opinion on Pharmacotherapy, 11, 1003–1014.
This article provided a review of the history of antiemetic development and use, a brief overview of relevant professional guidelines, and recent research on pharmacokinetics and outcomes with palonosetron. A meta-analysis on studies with two different doses of palonosetron was provided. No specific search strategy or research evaluation approach was reported.
Pharmacokinetics and effects of palonosetron suggest it may have greater efficacy, particularly with delayed nausea and vomiting. This review points to a number of issues that should be considered in the design of future studies in this area.