Shin, S.H., Lee, H.S., Kim, Y.S., Choi, Y.J., Kim, S.G., Kwon, H.C., . . . Chung, J.S. (2014). Clinical usefulness of hydromorphone-OROS in improving sleep disturbances in Korean cancer patients: A multicenter, prospective, open-label study. Cancer Research and Treatment, 46, 331.
To evaluate the efficacy of hydromorphone-OROS (HM-OROS) in the treatment of sleep disturbances associated with cancer-related pain
Patients took an equianalgesic dose of HM-OROS for two weeks. The dose of HM-OROS was individualized and based on the total dose of previous opioids that were administered on the last day of the screening phase.
Multicenter, prospective, open-label study with a pre- and post-test
HM-OROS improved sleep disturbances in patients with moderate to severe cancer-related pain.
HN-OROS may be an effective drug to treat cancer-related pain and improve sleep disturbance.