Shpilberg, O., Blumenthal, R., Sofer, O., Katz, Y., Chetrit, A., Ramot, B., . . . Ben-Bassat, I. (1995). A controlled trial of tranexamic acid therapy for the reduction of bleeding during treatment of acute myeloid leukemia. Leukemia & lymphoma, 19, 141–144.
During induction, there was no difference between the study and control regarding period of thrombocytopenia less than 20, number of bleeding episodes, number of platelet or RBC transfusions, or score of bleeding events. During consolidation, there was significantly less bleeding in the TA group, resulting in less platelets (3.7 +/- 4.1 [p < .05]); there was no significant difference in the number of RBCs transfused. No thromboembolic event or fatal bleeds occurred in either group.