Simino, G.P., Marra, L.P., Andrade, E.I., Acurcio, F.A., Reis, I.A., de Araujo, V.E., & Cherchiglia, M.L. (2016). Efficacy, safety and effectiveness of ondansetron compared to other serotonin-3 receptor antagonists (5-HTRAs) used to control chemotherapy-induced nausea and vomiting: Systematic review and meta-analysis. Expert Review of Clinical Pharmacology, 9, 1183–1194.
STUDY PURPOSE: To assess the effectiveness and safety of 5HT3s for antiemetic prophylaxis
TYPE OF STUDY: Meta-analysis and systematic review
PHASE OF CARE: Active antitumor treatment
Meta-analysis of ondansetron versus granisetron or tropisetron did not show any significant differences in the risk of CINV. The risk ratio with palonosetron versus ondansetron was lower (–1.28, p = 0.033).
The findings suggested a similar efficacy of the various 5HT3 preparations for CINV prophylaxis.
Some regimens contained a steroid and some did not. Meta-analysis did not consider all possible drug combinations. Varied emetogenicity of chemotherapy regimens was present.
The findings support the general efficacy of various 5HT3 drugs for CINV prophylaxis.