Spathis, A., Dhillan, R., Booden, D., Forbes, K., Vrotsou, K., & Fife, K. (2009). Modafinil for the treatment of fatigue in lung cancer: a pilot study. Palliative Medicine, 23, 325–331.
To determine the feasibility of conducting a randomized, controlled trial to assess the efficacy and safety of modafinil for the treatment of fatigue in patients with lung cancer.
Patients with non-small cell lung cancer (NSCLC) took modafinil in a fixed dose-titration schedule (100 mg daily on day 1 and increasing in the second week to 200 mg daily) for 14 days.
This was an intervention feasibility study.
It is feasible to conduct randomized, controlled trials.
The study had a small sample size, with less than 30 patients.