Tatsushima, Y., Egashira, N., Narishige, Y., Fukui, S., Kawashiri, T., Yamauchi, Y., & Oishi, R. (2013). Calcium channel blockers reduce oxaliplatin-induced acute neuropathy: A retrospective study of 69 male patients receiving modified FOLFOX6 therapy. Biomedicine & Pharmacotherapy, 67, 39-42.
Determine whether treatment with calcium channel blockers prevented oxaliplatin-induced acute neuropathy
Retrospective chart review was conducted to obtain data, and analysis was performed to determine differences in neuropathy symptoms between patients who were and were not on calcium channel blockers.
PHASE OF CARE: Active antitumor treatment
Two-group, retrospective, cross-sectional
The incidence of acute neurotoxicity was lower in the calcium channel group; however, no differences existed related to chronic neuropathy.
Patients receiving calcium channel blockers may experience less acute neurotoxicity than those not receiving calcium channel blockers, but more well-designed studies are needed before any conclusions can be made.
More studies are needed before any clinical implications can be made.