Tian, W., Wang, Z., Zhou, J., Zhang, S., Wang, J., Chen, Q., … Lin, T. (2010). Randomized, double-blind, crossover study of palonosetron compared with granisetron for the prevention of chemotherapy-induced nausea and vomiting in a Chinese population. Medical Oncology, 28, 71-78.
To compare single-dose palonosetron with single-dose granisetron in the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) with cisplatin for moderately emetogenic chemotherapy
Subjects were stratified according to having chemotherapy with cisplatin and were randomly assigned to either palonosetron during cycle 1 and granisetron during cycle 2 or the opposite sequence of antiemetics. Patients receive 0.25 mg IV palonosetron or 3 mg IV granisetron 30 minutes prior to chemotherapy infusion. Other drugs with antiemetic efficacy, including dexamethasone, were not permitted; however, use of rescue medication was allowed. Use of rescue medications was standardized. Patients used diaries to record the number of emetic episodes.
The study was conducted at multiple sites in China.
All patients were in active treatment.
This was a randomized, double-blind, crossover comparative trial.
The efficacy of single-dose, 0.25-mg palonosetron was not inferior to 3 mg granisetron for the prevention of CINV in the acute, delayed, and overall periods.
Palonosetron appears to have similar efficacy as granisetron for prevention of CINV in patients receiving MEC.