Topkan, E., & Karaoglu, A. (2006). Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma. Oncology, 71(5–6), 354–360.
This study was prospectively designed.
The primary goal was complete resolution of CRTID. The secondary goal was prevention of treatment delays attributed to diarrhea.