Uchida, M., Kato, K., Ikesue, H., Ichinose, K., Hiraiwa, H., Sakurai, A., . . . Oishi, R. (2013). Efficacy and safety of aprepitant in allogeneic hematopoietic stem cell transplantation. Pharmacotherapy, 33, 893–901.
To evaluate the efficacy and safety of aprepitant added to standard antiemetic regimens in high-dose chemotherapy for allogeneic hematopoietic stem cell transplantation
Retrospective medical record review of electronic medical records
The use of aprepitant with granisetron was highly effective in decreasing vomiting and nausea in patients receiving hematopoietic stem cell transplantations. There was no increase in adverse events. There were therapeutic outcomes.
The combination of granisetron and aprepitant was highly effective for chemotherapy-induced nausea and vomiting in patients receiving hematopoietic stem cell transplantations. Nurses should know that the combination did not increase side effects or affect engraftment.