Wanko, S.O., Broadwater, G., Folz, R.J., & Chao, N.J. (2006). Diffuse alveolar hemorrhage: Retrospective review of clinical outcome in allogeneic transplant recipients treated with aminocaproic acid. Biology of Blood and Marrow Transplantation, 12, 949–953.
Fourteen allogeneic patients with 15 episodes of diffuse alveolar hemorrhage (DAH) were treated with Solu-Medrol®; eight of these patients also received aminocaproic acid 1,000 mg IV every six hours.
Overall 100-day survival was 60%, and the median transplantation survival was 99 days. Patients treated with aminocaproic acid improved to a 100-day mortality of 44% and 167-day median transplant survival, compared to those not treated with aminocaproic acid with an 83% 100-day mortality and 96.5-day median transplant survival.