Yeom, C. H., Jung, G. C., & Song, K. J. (2007). Changes of terminal cancer patients’ health-related quality of life after high dose vitamin C administration. Journal of Korean Medical Science, 22, 7–11.
Patients were given an intravenous administration of 10 g of vitamin C twice daily with a three-day interval and an oral intake of 4 g of vitamin C daily for one week. Outcomes were assessed at baseline and at the end of the intervention.
Department of Family medicine, Myungji-Hospital, Kwandong University College of Medicine
Patients were undergoing the end of life phase of care.
The study was a prospective, nonrandomized trial.
European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30)
The vitamin C intervention significantly improved fatigue in patients after one week of treatment, as mean fatigue scores dropped from 52 (standard deviation [SD] = 24) to 40 (SD = 19) (p < 0.001).