Talking to Your Patient About a Germline Variant of Uncertain Significance

A variant of uncertain significance (VUS) detected through germline biomarker testing can be challenging to explain to patients. When a variant is classified as a VUS, there is not enough information available to determine whether it is pathogenic or benign. A VUS is not actionable. Use this FAQ sheet to learn about a VUS, so the next time your patient has questions about this finding, you are prepared to provide guidance.